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Moringa oleifera is known as the drumstick tree. It is a tropical plant that is widely distributed across India and is used locally to cure over 300 ailments. It is also reported to have inhibitory actions against several viruses. The researchers in India extracted and analysed 19 phytochemicals from M. oleifera leaves using liquid chromatography-mass spectrometry (LC-MS). Advice on optimising a liquid chromatography system can be found in the article, Troubleshooting Retention Time Changes in (U)HPLC – a Systematic Approach.
The researchers used computer modelling to see which of the phytochemicals identified from the drumstick plant might inhibit the SARS-CoV-2 virus. They found that several of the phytochemicals showed a high binding affinity with the virus and could act as virus inhibitors. The compound with the highest activity was apigenin-7-O-rutinoside and the team also found that several of the phytochemicals had antioxidant properties which would ameliorate the post-COVID secondary infection.
Reference: Potentiality of Moringa oleifera against SARS-CoV-2: identified by a rational computer aided drug design method. Debanjan Sen et al. J Biomol Struct Dyn. 2021.
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